Morphological and Functional Alterations in Zebrafish (Danio rerio) Liver after Exposure to Two Ecologically Relevant Concentrations of Lead

Lead (Pb) is a non-essential, highly toxic, and persistent element widely recognized as one of the most concerning pollutants. It listed on Priority List Hazardous Substances. Widespread environmental contamination from Pb serious issue for human health wildlife. In fish, mainly accumulates in liver, which key component metal detoxification excretion processes. this study, we investigated, first time, morphological functional injuries induced zebrafish (Danio rerio) liver by two very low environmentally relevant concentrations (2.5 5 μg/L) after 48, 96, 192 h exposure. We observed significant histological alterations all exposed samples, it was demonstrated that extent increased with dose exposure time. The common modifications were congestion blood vessels sinusoids, cytoplasmic vacuolizations, parenchyma dyschromia, macrophage proliferation. administration also resulted increase lipid content upregulation genes are involved (mtf1) defensive response against oxidative stress (sod1 cat). show even doses can disrupt morphology function.